International Collaborative Papers

1. Kudo K, Liu T, Murakami T, Goodwin J, Uwano I, Yamashita F, Higuchi S, Wang Y, Ogasawara K, Ogawa A, Sasaki M.: “Oxygen Extraction Fraction Measurement using Quantitative Susceptibility Mapping: Comparison with Positron Emission Tomography”, JCBFM, 2016 Aug;36(8):1424-33 (2016) [Overseas journal]
2. Cui Yi, Song J, Pollom E, Alagappan M, Shirato H, Chang DT, Koong AC, Li R: “Quantitative analysis of 18F-fluorodeoxyglucose positron emission tomography identifies novel prognostic imaging biomarkers in locally advanced pancreatic cancer patients treated with stereotactic body radiation therapy” Int J Radiat Onco Biol Phys, 2016 Sep 1;96(1):102-9.doi: 10.1016/j.ijrobp. 2016.04.034 (2016) [Overseas journal] *i) ○
3. Wu J, Cui Y, Sun X, Cao G, Li B, Ikeda DM, Kurian AW, Li R.: “Unsupervised clustering of quantitative image phenotypes reveals breast cancer subtypes with distinct prognoses and molecular pathways”, Clin Cancer Res. [Overseas journal] *i) ○
4. Cui Y, Tha KK, Terasaka S, Yamaguchi S, Wang J, Kudo K, Xing L, Shirato H, Li R: “Prognostic imaging biomarkers in glioblastoma: development and independent validation on the basis of multiregion and quantitative analysis of MR images”, Radiology, 2016, 278(2): 546-53 (2016) [Overseas journal] *i) ○
5. Rankin EB, Nam JM, Giaccia AJ: “Hypoxia: Signaling the Metastatic Cascade”, Trends in Cancer, 2, 295–304, (2016) [Overseas journal] *i) ○
6. Bennink E, Oosterbroek J, Kudo K, Viergever MA, Velthuis BK, de Jong HW: “A Fast Non-Linear Regression Method for CT Brain Perfusion Analysis”, J Med Imaging , 2016 Apr;3(2):026003. doi: 10.1117/1.JMI.3.2.026003. Epub 2016 Jun 16 (2016) [Overseas journal]
7. Roseman DA, Hwang SJ, Oyama-Manabe N, Chuang ML, O’Donnell CJ, Manning WJ, Fox CS: “Clinical associations of total kidney volume: The framingham heart study”, NDT; – European Renal Association (2016) [Overseas journal]

Other Original Papers

- major papers only

Japanese Journals (including those in English)

1. Shirato H, Nishioka K: “iGold – in vivo metallic fiducial markers in prostate cancer / liver cancer”, Radiotherapy BOOK 2016, Rad Fan, November Extra edition (2016)
2. Shimizu S: “Intensity modulated proton beam therapy”, Ishiyaku Pub, Inc., Journal of Clinical and Experimental Medicine, Igaku no ayumi, 257(1), pp. 19-24 (2016)
3. Shimizu S: “Advanced proton beam therapy – intensity modulated / real-time tumor tracking / cone beam CT –”, Life Medicom, Current Therapy, 34(5), pp. 58-63 (2016)
4. Shimizu S: “Comprehensive guide to heavy particle therapy / proton beam therapy at the Proton beam irradiation facility and dedicated installations at Hokkaido University”, Kenkyu Kikaku Publisher, pp. 104-105 (2016)
5. Sakuhara Y, Abo D, Soyama T, Morita R, Kudo K: “Puncture and drainage ―Basics and application of IVR”, Transdermal sclerotherapy for cystic lesions, Feature article, Rad Fan, 14(9):49-51 (2016)
6. Abo D, Sakuhara Y, Soyama T, Morita R, Kudo K, Tamoto E, Nakamura T, Hirano S: “Chapter 3, Alteration of blood flows during pancreatectomy ― focusing on techniques and procedures”, Journal of biliary tract & pancreas (Kan to Sui), 37(5) (2016)
7. Manabe N: “Basics of cardiac MRI”, “Cardiomyopathy”, Koredakeha Shitteokitai Shinzo Kekkan Shikkanno Gazosindan in Japanese (Basics of diagnostic imaging for cardiac and vascular diseases), Gakken Medical Shujunsha Co.,Ltd. pp. 24-29, pp. 110-119  (2016)
8. Manabe N: “MRI of cardiac sarcoidosis”, Featuring sarcoidosis, January, Clinical Imageology (2016)
9. Manabe N: “Cardiac Perfusion of MRI and CT (in comparison)” Japan Association of Radiological Technologists-magazine hosted 7th Heart CT (2016)
10. Harada T, Kudo K: “Present conditions and future of QSM”, A Monthly Journal of Medical Imaging and Information, Sangyo Kaihatsukiko, Inc. (2016)

Overseas Journals

1. Katoh N, Soda I, Tamamura H, Takahashi S, Uchinami Y, Ishiyama H, Ota K, Inoue T, Onimaru R, Shibuya K, Hayakawa K, Shirato H: “Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system”, Radiat Oncol. 2017 Jan 5;12(1):3. doi: 10.1186/s13014-016-0742-3. (2017)*i)
2. Hatano K, Kamishima T, Sutherland K, Kato M, Nakagawa I, Ichikawa S, Kawauchi K, Saitou S, Mukai M: “A reliability study using computer-based analysis of finger joint space narrowing in rheumatoid arthritis patients”, Rheumatol Int. 2017 Feb;37(2):189-195. doi: 10.1007/s00296-016-3588-y. (2017)
3. Sakano R, Saito K, Kamishima T, Nishida M, Horie T, Noguchi A, Kono M, Sutherland K, Atsumi T: “Power Doppler signal calibration in the finger joint between two models of ultrasound machine: a pilot study using a phantom and joints in patients with rheumatoid arthritis”, Acta Radiol. 2017 Jan 1:284185116685923. doi: 10.1177/0284185116685923 (2017)
4. Mizumoto M, Murayama S, Akimoto T, Demizu Y, Fukushima T, Ishida Y, Oshiro Y, Numajiri H, Fuji H, Okumura T, Shirato H, Sakurai H: “Long-term follow-up after proton beam therapy for pediatric tumors: a Japanese national survey”, Cancer Sci. 2017 Mar;108(3):444-447. doi: 10.1111/cas.13140. PubMed PMID: 28004469; PubMed Central PMCID: PMC5378281 (2017)
5. Fujima N, Yoshida D, Sakashita T, Homma A, Tsukahara A, Shimizu Y, Tha KK, Kudo K, Shirato H: “Prediction of the treatment outcome using intravoxel incoherent motion and diffusional kurtosis imaging in nasal or sinonasal squamous cell carcinoma patients”, Eur Radiol. 2017 Mar;27(3):956-96 (2017) *i)
6. Yoshimura T, Kinoshita R, Onodera S, Toramatsu C, Suzuki R, Ito YM, Takao S, Matsuura T, Matsuzaki Y, Umegaki K, Shirato H, Shimizu S: “NTCP modeling analysis of acute hematologic toxicity in whole pelvic radiation therapy for gynecologic malignancies – A dosimetric comparison of IMRT and spot-scanning proton therapy (SSPT)”, Phys Med. 2016 Sep;32(9):1095-102. doi: 10.1016/j.ejmp.2016.08.007. (2016) *i)
7. Uchinami Y, Myojin M, Takahashi H, Harada K, Shimizu S, Hosokawa M: “Prognostic factors in clinical T1N0M0 thoracic esophageal squamous cell carcinoma invading the muscularis mucosa or submucosa”, Radiat Oncol., 2016 Jun 21;11:84. doi: 10.1186/s13014-016-0660-4. (2016)
8. Onimaru R, Onishi H, Shibata T, Hiraoka M, Ishikura S, Karasawa K, Matsuo Y, Kokubo M, Shioyama Y, Matsushita H, Ito Y, Shirato H: “Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer (JCOG0702): Results for the group with PTV ≧100 cc”, Radiother Oncol. 2016 in press. doi: 10.1016/j.radonc.2016.11.022 (2016)
9. Soyama T, Sakuhara Y, Kudo K, Abo D, Wang J, Ito YM, Hasegawa Y, Shirato H: “Comparison of conventional ultrasonography and ultrasonography-computed tomography fusion imaging for target identification using digital/real hybrid phantoms: a preliminary study”, J Med Ultrason (2001). 2016 Jul;43(3):327-35. doi: 10.1007/s10396-016-0704-2 (2016)
10. Fujima N, Osanai T, Shimizu Y, Yoshida A, Harada T, Nakayama N, Kudo K, Houkin K, Shirato H: “Utility of noncontrast-enhanced time-resolved four-dimensional MR angiography with a vessel-selective technique for intracranial arteriovenous malformations”, J Magn Reson Imaging. 2016 Oct;44(4):834-45. doi: 10.1002/jmri.25222. (2016) *i)
11. Hamaguchi H, Tha KK, Sugimori H, Nakanishi M, Nakagawa S, Fujiwara T, Yoshida H, Takamori S, Shirato H. “Effect of respiratory and cardiac gating on the major diffusion-imaging metrics” Neuroradiol J. 2016 Aug;29(4):254-9. doi: 10.1177/1971400916643337. (2016) *i)
12. Fujima N, Sakashita T, Homma A, Hirata K, Shiga T, Kudo K, Shirato H: “Glucose Metabolism and Its Complicated Relationship with Tumor Growth and Perfusion in Head and Neck Squamous Cell Carcinoma”, PLoS One. 2016 Nov 8;11(11): e0166236. doi: 10.1371/journal.pone.0166236. (2016) *i)
13. Fujima N, Sakashita T, Homma A, Shimizu Y, Yoshida A, Harada T, Tha KK, Kudo K, Shirato H: “Advanced diffusion models in head and neck squamous cell carcinoma patients: Goodness of fit, relationships among diffusion parameters and comparison with dynamic contrast-enhanced perfusion”, Published online: October 27, 2016 (2016) *i)
14. Sakashita T, Kamishima T, Sugimori H, Tang M, Noguchi A, Kono M, Sutherland K, Tatsuya A: “Pixel-by-Pixel Arterial Spin Labeling Blood Flow Pattern Variation Analysis for Discrimination of Rheumatoid Synovitis: A Pilot Study”, Magn Reson Med Sci. 05/2016; doi:10.2463/mrms.tn.2015-0145 (2016)
15. Ono Y, Kashihara R, Yasojima N, Kasahara H, Simizu Y, Tamura K, Tsutsumi K, Sutherland K, Koike T, Kamishima T: “Tomosynthesis can Facilitate Accurate Measurement of Joint Space Width under the Condition of the Oblique Incidence of X-rays in Rheumatoid Arthritis Patients”, Br J Radiol. 06/2016; 89(1062):20150967. doi: 10.1259/bjr.20150967 (2016)
16. Yamada T, Miyamoto N, Matsuura T, Takao S, Fujii Y, Matsuzaki Y, Koyano H, Umezawa M, Nihongi H, Shimizu S, Shirato H, Umegaki K: “Optimization and evaluation of multiple gating beam delivery in a synchrotron-based proton beam scanning system using a real-time imaging technique”, Phys Med. 2016 Jul;32(7):932-7. doi: 10.1016/j.ejmp.2016.06.002. (2016) *i) ii)
17. Kanehira T, Matsuura T, Takao S, Matsuzaki Y, Fujii Y, Fujii T, Ito YM, Miyamoto N, Inoue T, Katoh N, Shimizu S, Umegaki K, Shirato H: “Impact of Real-Time Image Gating on Spot Scanning Proton Therapy for Lung Tumors: A Simulation Study”, Int J Radiat Oncol Biol Phys. 2016 Sep 28. pii: S0360-3016(16)33238-2. doi: 10.1016/j.ijrobp.2016.09.027. (2016) *i)
18. Maeda K, Yasui H, Yamamori T, Matsuura T, Takao S, Suzuki M, Matsuda A, Inanami O, Shirato H: “A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo- Pentofuranosyl) Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam”, PLoS One. 2016 Nov 22;11(11):e0166848. doi: 10.1371/journal.pone.0166848. (2016)
19. Onimaru R, Onishi H, Shibata T, Hiraoka M, Ishikura S, Karasawa K, Matsuo Y, Kokubo M, Shioyama Y, Matsushita H, Ito Y, Shirato H: “Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer (JCOG0702): Results for the group with PTV⩾100cc”, Radiother Oncol. 2017 Feb;122(2):281-285. doi: 10.1016/j.radonc.2016.11.022. Epub 2016 Dec 16. PubMed PMID: 27993416. (2016)
20. Suzuki T, Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Yoshida D, Fujima N, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Suzuki F, Fukuda S: “Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis”, Eur Arch Otorhinolaryngol. 2016 Oct;273(10):3331-6. doi: 10.1007/s00405-016-3933-5. (2016)
21. Mizumoto M, Murayama S, Akimoto T, Demizu Y, Fukushima T, Ishida Y, Oshiro Y, Numajiri H, Fuji H, Okumura T, Shirato H, Sakurai H: “Proton beam therapy for pediatric malignancies: a retrospective observational multicenter study in Japan”, Cancer Med. 2016 Jul;5(7):1519-25. doi: 10.1002/cam4.743. (2016)
22. Okamoto S, Shiga T, Yasuda K, Watanabe S, Hirata K, Nishijima KI, Magota K, Kasai K, Onimaru R, Tuchiya K, Kuge Y, Shirato H, Tamaki N: “The reoxygenation of hypoxia and the reduction of glucose metabolism in head and neck cancer by fractionated radiotherapy with intensity-modulated radiation therapy”, Eur J Nucl Med Mol Imaging. 2016 Nov;43(12):2147-2154. (2016)
23. Hamada T, Sutherland K, Ishikawa M, Miyamoto N, Honma S, Shirato H, Honma K: “In vivo imaging of clock gene expression in multiple tissues of freely moving mice”, Nat Commun. 2016 Jun 10;7:11705. doi: 10.1038/ncomms11705. (2016) *i)
24. Narita H, Tha KK, Hashimoto N, Hamaguchi H, Nakagawa S, Shirato H, Kusumi I: “Mean kurtosis alterations of cerebral white matter in patients with schizophrenia revealed by diffusion kurtosis imaging”, Prog Neuropsychopharmacol Biol Psychiatry. 2016 Nov 3;71:169-75. doi: 10.1016/j.pnpbp.2016.07.011. (2016) *i)
25. Niibe Y, Nishimura T, Inoue T, Karasawa K, Shioyama Y, Jingu K, Shirato H: “Oligo-recurrence predicts favorable prognosis of brain-only oligometastases in patients with non-small cell lung cancer treated with stereotactic radiosurgery or stereotactic radiotherapy: a multi-institutional study of 61 subjects”, BMC Cancer, 2016 Aug 19;16(1):659. doi: 10.1186/s12885-016-2680-8. (2016)
26. Homma A, Hatakeyama H, Mizumachi T, Kano S, Sakashita T, Kuramoto R, Nakamaru Y, Onimaru R, Tsuchiya K, Yoshida D, Yasuda K, Shirato H, Fukuda S: “ A Retrospective Study of G-Tube Use in Japanese Patients Treated with Concurrent Chemoradiotherapy for Hypopharyngeal Cancer”, PLoS One. 2016 Aug 24;11(8):e0161734. doi: 10.1371/journal.pone.0161734. (2016)
27. Hashimoto A, Oikawa T, Hashimoto S, Sugino H, Yoshikawa A, Otsuka Y, Handa H, Onodera Y, Nam JM, Oneyama C, Okada M, Fukuda M, Sabe H: “P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance”, J Cell Biol. 2016 Apr 11;213(1):81-95. doi: 10.1083/jcb.201510002. (2016) *i)
28. Komiya Y, Onodera Y, Kuroiwa M, Nomimura S, Kubo Y, Nam JM, Kajiwara K, Nada S, Oneyama C, Sabe H, Okada M: “The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transition”, Oncogenesis, 2016 Sep 12;5(9):e258. doi: 10.1038/oncsis.2016.59. (2016) *i)
29. Otsuka Y, Sato H, Oikawa T, Onodera Y, Nam JM, Fukunaga K, Hatanaka KC, Hatanaka Y, Matsuno Y, Fukuda S, Sabe H: “High expression of EPB41L5, an integral component of the Arf6-driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the tongue”, Cell Commun Signal, 2016, 14:28. DOI: 10.1186/s12964-016-0151-0 (2016) *i)
30. Kazumata K, Tha KK, Narita H, Shichinohe H, Ito M, Uchino H, Abumiya T: “Investigating Brain Network Characteristics Interrupted by Covert White Matter Injury in Patients with Moyamoya Disease: Insights from Graph Theoretical Analysis”, World Neurosurg. 2016 May;89:654-665.e2. (2016)
31. Tan C, Shichinohe H, Wang Z, Hamauchi S, Abumiya T, Nakayama N, Kazumata K, Ito T, Kudo K, Takamoto S, Houkin K: “Feasibility and efficiency of human bone marrow stromal cell culture with allogeneic platelet lysate-supplementation for cell therapy against stroke”, Stem Cells Int. 2016;2016:6104780. Epub 2016 Oct 20. (2016)
32. Kazumata K, Tha KK, Narita H, Ito YM, Shichinohe H, Ito M, Uchino H, Abumiya T: “Characteristics of Diffusional Kurtosis in Chronic Ischemia of Adult Moyamoya Disease: Comparing Diffusional Kurtosis and Diffusion Tensor Imaging”, AJNR Am J Neuroradiol. 2016 Aug;37(8):1432-9. doi: 10.3174/ajnr.A4728. (2016)
33. Watanabe S, Manabe O, Hirata K, Oyama-Manabe N, Hattori N, Kikuchi Y,　Kobayashi K, Toyonaga T, Tamaki N: “The usefulness of (18)f-fdg pet/ct for assessing methotrexate-associated lymphoproliferative disorder (mtx-lpd)”, BMC cancer, 2016;16:635 (2016)
34. Sugaya T, Oyama-Manabe N, Yamaguchi T, Tamaki N, Ishimaru S, Okabayashi H, Furuya J, Yoshida T, Igarashi Y, Igarashi K: “Visualization of collateral channels with coronary computed tomography angiography for the retrograde approach in percutaneous coronary intervention for chronic total occlusion”, Journal of cardiovascular computed tomography, 2016;10:128-134 (2016)
35. Noguchi A, Kato M, Kono M, Ohmura K, Ohira H, Tsujino I, Oyama-Manabe N, Oku K, Bohgaki T, Horita T, Yasuda S, Nishimura M, Atsumi T: “Bi-ventricular interplay in patients with systemic sclerosis-associated pulmonary arterial hypertension: Detection by cardiac magnetic resonance”, Modern rheumatology, 2016:1-8 (2016)
36. Manabe O, Yoshinaga K, Ohira H, Masuda A, Sato T, Tsujino I, Yamada A, Oyama-Manabe N, Hirata K, Nishimura M, Tamaki N: “The effects of 18-h fasting with low-carbohydrate diet preparation on suppressed physiological myocardial (18)f-fluorodeoxyglucose (fdg) uptake and possible minimal effects of unfractionated heparin use in patients with suspected cardiac involvement sarcoidosis”, J Nucl Cardiol. 2016;23:244-252 (2016)
37. Manabe O, Oyama-Manabe N, Naya M, Aikawa T, Sakakibara M, Tsutsui H, Tamaki N: “ Pitfalls of 18f-fdg pet for evaluating myocardial viability”, J Nucl Cardiol.: official publication of the American Society of Nuclear Cardiology , 2016 (2016)
38. Manabe O, Hirata K, Shozo O, Shiga T, Uchiyama Y, Kobayashi K, Watanabe S, Toyonaga T, Kikuchi H, Oyama-Manabe N, Tamaki N: “18f-fluoromisonidazole (fmiso) pet may have the potential to detect cardiac sarcoidosis”, J Nucl Cardiol. 2016 (2016)
39. Aikawa T, Naya M, Oyama-Manabe N, Maekawa S, Nambu H, Mitsuyama H, Hirata K, Kanno-Okada H, Tsutsui H: “18f-fdg pet findings of pericardial lymphangiohemangioma”, J Nucl cardiol.: official publication of the American Society of Nuclear Cardiology, 2016 (2016)
40. Kubo K, Kawakami H, Kuwatani M, Nishida M, Kawakubo K, Kawahata S, Taya Y, Kubota Y, Amano T, Shirato H, Sakamoto N: “Liver elasticity measurement before and after biliary drainage in patients with obstructive jaundice: a prospective cohort studya prospective cohort study”, BMC Gastroenterol. 2016 Jul 8;16(1):65. doi: 10.1186/s12876-016-0479-3. (2016)
41. Uwano I, Sasaki M, Kudo K, Boutelier T, Kameda H, Mori F, Yamashita F: “Tmax Determined Using a Bayesian Estimation Deconvolution Algorithm Applied to Bolus Tracking Perfusion Imaging: A Digital Phantom Validation Study”, Magn Reson Med Sci. 2017 Jan 10;16(1):32-7. (2016)
42. Hashimoto A, Oikawa T, Hashimoto S, Sugino H, Yoshikawa A, Otsuka Y, Handa H, Onodera Y, Nam JM, Oneyama C, Okada M, Fukuda M, Sabe H.： “P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance”, J Cell Biol., 2016 Apr 11;213(1):81-95. doi: 10.1083/jcb.201510002. Epub 2016 Apr 4.  (2016) *i)