On 14-15 March 2017, together with Department of Radiation Oncology, Stanford University, Global Station for Quantum Medical Science and Engineering jointly organized the 4th GI-CoRE Medical Science and Engineering Symposium as a closed gathering at Hokkaido University. This year’s symposium featured in-depth scientific discussion to establish internationally acceptable models and standards within the field of radiation oncology for the estimation of normal tissue complication probability (NTCP) and tumor control probability (TCP) for photon, proton, and carbon therapy as well as for new biochemical modifiers of these radiation beams. For the discussion, world top researchers joined from Johns Hopkins University, Mayo Clinic, MD Anderson Cancer Center, University Medical Center Groningen, Osaka University, National Institute of Radiological Science, Kobe Pharmaceutical University in addition to Stanford University and Hokkaido University. To develop the global consensus, a wide range of topics including big data analysis, theoretical and experimental radiation biology, cancer care coordination, medical economics were covered and the optimal means of assessing treatment efficacy for particle beam therapy were very actively discussed by the researchers.